ACTIVASE PACKAGE INSERT PDF

Contraindications Cathflo Activase should not be administered to patients with known hypersensitivity to alteplase or any component of the formulation. Using Cathflo Activase in patients with infected catheters may release a localized infection into the systemic circulation. As with all catheterization procedures, care should be used to maintain aseptic technique. Reminder: This feature is intended for US healthcare professionals only. You should receive a response within 2 business days. Activase alteplase for injection, for intravenous use

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Contraindications Cathflo Activase should not be administered to patients with known hypersensitivity to alteplase or any component of the formulation. Using Cathflo Activase in patients with infected catheters may release a localized infection into the systemic circulation. As with all catheterization procedures, care should be used to maintain aseptic technique. Reminder: This feature is intended for US healthcare professionals only.

You should receive a response within 2 business days. Activase alteplase for injection, for intravenous use Open the package containing the transfer device by peeling the paper label off the package. Remove the protective cap from the other end of the Indications Activase alteplase is indicated for the treatment of acute ischemic stroke.

Exclude intracranial hemorrhage as the primary cause of stroke signs and symptoms prior to initiation of treatment. Initiate treatment as soon as possible but within 3 hours after symptom onset.

DO NOT It is a sterile, purified glycoprotein of amino acids.

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Cathflo Activase

The manufacturing process involves secretion of the enzyme Alteplase into the culture medium by an established mammalian cell line Chinese hamster ovary cells into which the cDNA for Alteplase has been genetically inserted. Cathflo Activase Alteplase for injection is a sterile, white to pale yellow, lyophilized powder for intracatheter instillation for restoration of function to central venous access devices following reconstitution with Sterile Water for Injection, USP. Each vial of Cathflo Activase contains 2. Cathflo Activase - Clinical Pharmacology Alteplase is an enzyme serine protease that has the property of fibrin-enhanced conversion of plasminogen to plasmin. It produces limited conversion of plasminogen in the absence of fibrin.

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PRECAUTIONS General Catheter dysfunction may be caused by a variety of conditions other than thrombus formation, such as catheter malposition, mechanical failure, constriction by a suture, and lipid deposits or drug precipitates within the catheter lumen. These types of conditions should be considered before treatment with Cathflo Activase. Excessive pressure should be avoided when Cathflo Activase is instilled into the catheter. Such force could cause rupture of the catheter or expulsion of the clot into the circulation. Bleeding The most frequent adverse reaction associated with all thrombolytics in all approved indications is bleeding 3,4.

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Institute parenteral anticoagulation near the end of or immediately following the Activase infusion when the partial thromboplastin time or thrombin time returns to twice normal or less. Reconstitute using aseptic technique. Do not add other medication to solutions containing Activase. Slight foaming is not unusual; let stand undisturbed for several minutes to allow large bubbles to dissipate.

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